Pharmacognostic Standardization and Quality Profiling of Mangifera indica Bark Powder for Comprehensive Analysis of Neurological Disorders
Keywords:
Mangifera indica, HPTLC, quality control, polyphenols, Mangiferin, mass spectrometry, flavonoids, phytochemical standardization.Abstract
The therapeutic efficacy of medicinal plants is attributed to polyphenolic chemicals, which are essential bioactive components. The bark of the mango plant, Mangifera indica, is a rich source of polyphenols that have antibacterial, anti-inflammatory, and antioxidant properties. For plant-derived products to be consistent, effective, and quality controlled, however, thorough phytochemical standardisation is necessary. The purpose of this research is to provide a comprehensive phytochemical profile by utilising High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS) to analyse and interpret the polyphenolic content of Mangifera indica bark powder.Mangifera indica bark powder methanolic extracts were made and then separated chromatographically using HPLC in conjunction with photodiode array (PDA) detection. Acetonitrile and aqueous formic acid were used as the mobile phase in a gradient elution technique using a reverse-phase C18 column. Major polyphenolic components, such as Mangifera, quercetin, gallic acid, catechin, and ellagic acid, were identified and quantified using standard reference compounds using UV detection at 280 nm. The structural identity and fragmentation patterns of the identified polyphenols were further confirmed by LC-MS analysis.According to the study,Mangifera is the main component of Mangifera indica bark, which is a strong source of polyphenolic chemicals. Researchers studied the pharmacognostic characteristics of Mangifera indica’s bark. Organoleptic studies of the air-dried bark powdered rind revealed character like brown colour, sweet odour and unique flavour taste. The physiochemical characteristics, which include drying loss, values for total ash, acid-insoluble ash, water-soluble ash, swelling index, and foaming index, were analyzed. Investigate the solubility and extractive value of various solvents, such as methanol, ethanol, hydroalcohol, ethyl acetate, petroleum spirit, water and hexane. The ethanol solvent was found to have a higher extractive value. Flavonoids were found in the aqueous extract according to a preliminary phytochemical investigation.
References
A E Al-Snafi (2018) Pharmacological and therapeutic importance of Hibiscus sabdariffa- A review. 10(3), 451-475.
B Salehi, Mar Krochmal, B Marczak, D Skiba, J K Patra, S K Das, G Das, J B Popović Djordjević, A Z Kostić, N V Kumar, A Tripathi, A E Al-Snafi, Arserim Uçar, D A Konovalov, D Csupor, I Shukla, L Azmi, A P Mishra, J Sharifi-Rad, B Sawicka, N Martins, Y Taheri, B V T Fokou, R Capasso, M Martorell (2019) Convolvulus plant- A comprehensive review from phytochemical composition to pharmacy. 1–14.
A E Al-Snafi (2014) The pharmacology of Anchusa italica and Anchusa strigosa- A review. 6(4), 7-10.
A E Al-Snafi (2014) The pharmacological importance of Anethum graveolens- A review. 6(4), 11-13.
A E Al-Snafi (2013) Chemical constituents and pharmacological activities of Milfoil (Achillea santolina) - A Review. 5(3), 1373-1377.
A E Al-Snafi (2013) The Pharmaceutical importance of Althaea off icinalis and Althaea rosea: A Review. 5(3), 1387-1385.
Mangifera indica. http://www.theplantlist.org/tpl/record/kew-2362842
(2021) Major Tropical Fruits: Market Review.
S M Alzamora, S N Guerrero, A B Nieto, S L Vidales (2004) Conservación de Frutas y Hortalizas Mediante Tecnologías Combinadas: Manual de Capacitación.
E Mendoza, C Calvo (2010) Bromatología: Composición y Propiedades de Los Alimentos.
V C Quintero, G G Giraldo, J A Lucas, J L Vasco (2013) Physicochemical characterization of the common mango (Mangifera indica L.) during ripening process. 11, 10–18.
L S Atoche-Chauca, M W García-Siu (2017) Aprovechamiento de Residuos Agroindustriales (Cáscara de Mango) para la Formulación de Cupcakes.
(2019) The State of Food and Agriculture 2019: Moving forward on Food Loss and Waste Reduction.
S. Singh, S. Kawade, A. Dhar, S. Powar (2022) Analysis of mango drying methods and effect of blanching process based on energy consumption, drying time using multi-criteria decision-making. 8, 100500.
T.V.L. Nguyen, Q.D. Nguyen, P.B.D. Nguyen (2022) Drying kinetics and changes of total phenolic content, antioxidant activity and color parameters of mango and avocado pulp in refractance window drying. 72, 27–38.
J. Basulto, M. Moñino, A. Farran, E. Baladia, M. Manera, P. Cervera, M.D. Romero-de-Ávila, F. Miret, I. Astiasarán, J. Bonany (2014) Recomendaciones de manipulación doméstica de frutas y hortalizas para preservar su valor nutritivo. 18, 100–115.
Y.N. Hernández-Ruíz (2017) Deshidratación de Manzanas Tipo Granny Smith en Ventana Refractiva con Pretratamiento de Deshidratación Osmótica y Campo Eléctrico Moderado.
C.E. Díaz-Urbano (2018) Evaluación de Tecnologías de Secado en las Propiedades Fisicoquímicas del Banano (Cavendish Valery).
R. Chakraborty, A.K. Saha, P. Bhattacharya (2006) Modeling and simulation of parametric sensitivity in primary freeze-drying of foodstuffs. 49, 258–263.
C. Nindo (2008) Novel drying method for vegetables, fruits, herbs, and aquatic resources.
A. Carrascosa-Morelló (2019) Obtención de Aperitivos de Manzana con Efecto Probiótico Mediante Impregnación con Lactobacillus Paracasei.
R. Torres, E.J. Montes, O.A. Pérez, R.D. Andrade (2013) Relación del Color y del Estado de Madurez con las Propiedades Fisicoquímicas de Frutas Tropicales. 24, 51–56.
Safia Ejazul Haque Sheikh, Snober S. Mir (2013) Neurodegenerative Diseases: Multifactorial Conformational Diseases and Their Therapeutic Interventions. 8 pages. https://doi.org/10.1155/2013/563481
Johannes C.M. Schlachetzki, Soraya Wilke Saliba, Antonio Carlos Pinheiro de Oliveira (2013) Studying neurodegenerative diseases in culture models. 35, S92–S100. https://doi.org/10.1590/1516-4446-2013-1159
Departemen Kesehatan RI (2008) Farmakope Herbal Indonesia.
Jayaprakasam R, Ravi TK HPTLC and RP-HPLC methods for the estimation of Mangiferin in Mangifera indica extract and its formulation.
Harmita (2004) Petunjuk Pelaksanaan Validasi dan Cara Penggunaannya. 1(3), 117–135.
Lai L, Lin L, Lin J, Tsai T (2003) Pharmacokinetic Study of Free Mangiferin in Rats by Microdialysis Coupled with Microbore High-Performance Liquid Chromatography and Tandem Mass Spectrometry. 987, 367–374.
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