The Serotonin Hypothesis for Depression: A Comprehensive Study
Keywords:
Depression, antidepressants, pharmaceutical industry, psychiatric drug researchAbstract
It has been observed a sharp growth in the number of diagnoses of depression (under the MDD [Major Depressive Disorder] spectrum) in the last decades, accompanied by a similarly increase in sales of antidepressants in several societies, leading to depression being currently considered an epidemic (WHO). The predominant understanding of the cause for depression, the serotonin hypothesis, conveyed by 80% of the population, dates back to the 1960s, when the first antidepressants were being developed. This article sought to verify this state of affairs from the main literature available, starting from the original pharmacological development of antidepressants and their implication in the body’s physiology. Most of the literature gathered for this study did not validate the hypothesis as the most plausible main cause for depression, while nonetheless, this continues to be widespread by pharmaceutical industries and most medical practitioners as such.
References
J. Abraham (2010) Pharmaceuticalization of Society in Context: Theoretical, Empirical and Health Dimensions. 44(4), 603-622.
P.R. Albert, C. Benkelfat, L. Descarries (2012) The neurobiology of depression - revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms. 367, 2378-2381. https://doi.org/10.1098/rstb.2012.0190
J. R. Alonso (1998) Tratado de Fitomedicina. Bases Clínicas y Farmacológicas.
M.T. Berlinck (1999) A Dor. II(3), 46-58.
S. Caponi (2009) Uma análise epistemológica do diagnóstico de Depressão. 1(1). http://stat.saudeetransformacao.incubadora.ufsc.br/index.php/cbsm/article/view/1004/1120
A. Coppen, D. M. Shaw, J. P. Farrell (1963) Potentiation of the antidepressive effect of a monoamine-oxidase inhibitor by tryptophan. 79–81.
A. Coppen (1967) The biochemistry of affective disorders. 1237-1264. https://doi.org/10.1192/bjp.113.504.1237
P.J. Cowen, M. Browning (2015) What has serotonin to do with depression?. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471964/
C.I.L. Dunker (2021) Uma biografia da depressão.
D. Healy (1997) The age of anti-depressants.
D. Healy, M. Harris, P. Michael, D. Cattell, M. Savage, P. Chalasani (2001) Rise of mental disorders and mental illness - Treating more patients than ever before before: 1896 and 1996 compared.
D.L. Herzberg (2010) Happy pills in America: from Miltown to Prozac.
A.V. Horwitz, J.C. Wakefield (2010) A tristeza perdida: como a psiquiatria transformou a depressão em moda.
M.R. Kehl (2009) O tempo e o cão.
D-Y Kim, M Camilleri (2000) Serotonin: a mediator of the brain-intestinal brain link. 95(10), 2698.
J. R. Lacasse, J Leo (2005) Serotonin and depression: a disconnect between the advertisements and the scientific literature. 2(12), e392. https://doi.org/10.1371/journal.pmed.0020392
R Mabey (1988) The New Age Herbalist. How to use herbs for healing, nutrition, body care, and relaxation.
P. G. McLean, R. A. Borman, K Lee (2007) 5-HT in the enteric nervous system: bowel function and neuropharmacology. 30(1), 9-13.
S Okuda (2015) Pharmaceuticalization and Biomedicalization: An Examination of Depression-Related Problems in Japan. 5(8), 633-642. https://doi.org/10.17265/2159-5526/2015.08.004
V S Pereira, Hiroaki-Sato V A Hiroaki-Sato (2018) A brief history of antidepressant drug development: from tricyclics to beyond ketamine. 30(6), 307-322.
J Quevedo (2019) Depressão – Teoria e Clínica [Depression – Theory and Practice].
James M. Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey P. Rang (2020) Rang & Dale Farmacologia.
J. J. Schildkraut (1965) The catecholamine hypothesis of affective disorders: A review of the supporting evidence. 7, 524-533.
P.A. Shore (1971) Reserpine: A survey of its Pharmacology. 349-356.
M. J. P. Spink (2010) Cérebro, self e sociedade: uma conversa com Nikolas Rose [Brain, self and society: a conversation with Nikolas Rose]. 301-324. https://www.redalyc.org/pdf/4008/400838226016.pdf
Vieweh et al. Vieweh (2004) Tricyclic Antidepressants, QT Interval Prolongation, and Torsade de Pointes. 371–377.
M. M. Weber, H. M. Emrich (1988) Current and historical concepts of opiate treatment in psychiatric disorders. 3(3), 255-266. https://doi.org/10.1097/00004850-198807000-00007
R. Whitaker (2017) Anatomia de uma Epidemia [Anatomy of an Epidemic].
S. J. Williams, P. Martin, J. Gabe (2011) The pharmaceuticalization of society? An analysis framework. 33(5), 710-725.
D. T. Wong, J. S. Horng, F. P. Bymaster, K. L. Hauser, B. B. Molloy (1974) A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpro pylamine. 15, 471–479. https://www.sciencedirect.com/science/article/abs/pii/0024320574903452
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