London Journal of Medical and Health Research
type: channel
description: London Journal of Medical and Health Research London Journal of Medical and Health Research is focused on publishing groundbreaking ideas on theoretical and experimental research in all domains relating to medicine, diseases, advances in pharma and instruments. As a flagship scholarly journal, It is a peer-reviewed, international, indexed journal. The journal publishes high-quality research papers that are double-blind refereed. The journal has a dedicated team for reviewing articles of COVID-19 to make sure the research is valid and published first. It provides practical, theoretical, and managerial implications useful for further research development. The journal publishes high-quality research papers that are double-blind refereed. Authors and readers include academic researchers and educators, as well as scientists. SUBMIT MANUSCRIPT
publisher: Great Britain Journals Press
language: en
publication name: London Journal of Medical and Health Research
items: Stress Level in Parents with Premature Children Hospitalized in the Neonatal Intensive Care Unit in Hospital del Niño Dr. José Renán Esquivel During the Month of July 2022
items: Virtual Autism and the Influence of Screens on Children’s Development
items: Medical Women’s Mental Health Factors During the COVID-19 Pandemic
items: https://journalspress.uk/index.php/LJMHR/article/view/1961
items: A Comparison of Logistic Regression, Modified Logistic Regression and Naïve Bayes Models for Classifying HIV Viral load Suppression: The Case of Zombo District in Uganda
items: Motivation and Awareness Campaign: Institutional Evaluation of Facultade São Francisco De Assis
items: Impact of the Transplant Acceleration Program (PAT-MA) Phase I on Transplant Indicators in Maranhão, Brazil: A Retrospective Study
items: Neurological Manifestation of Chikungunya Virus and its Implication in the Pathogenesis of Guillain-Barré Syndrome: A Systematic Review of Clinical and Mechanistic Evidence
items: https://journalspress.uk/index.php/LJMHR/article/view/1912
items: The Effect of Dietary Fiber on Glycemic Control in Patients with Type 2 Diabetes Mellitus Receiving Oral Hypoglycemic Therapy
items: Diabetic Foot: A Multidisciplinary Approach to Limb Preservation
items: Evaluating Midwives’ Knowledge and Attitudes Regarding Pre-Eclampsia Management at Presbyterian Hospital
items: Calcium Hydroxide Induced Apexification in an Immature, Non-Vital Permanent Tooth – A Case Report
items: Effectiveness of Recombinant Enzymes in Cellulite Treatment: A Case Report
items: The Paradox of Airway Closure: From Protection to Pathology
items: Innovative Wound Dressings and Emerging Technologies for Wound Treatment: Trends and Perspectives – A Review
items: Cross-Scale Analogies between Astrophysics and Human Biology: Conceptual and Technological Parallels in the Study of Complex Systems
items: Pharmacotherapy of Heart Failure in Infants with Congenital Heart Disease
items: Is Primary Hypothyroidism Truly Primary? A Systems-based Reframing of Thyroid Dysfunction
items: Effectiveness and Safety of Treatment of Double Chin with Combined Enzymatic Therapy
items: Evolution of EU Legislation governing the presence of undesirable substances in animal feeds
items: Drug Poisoning: Toxicological Emergency
items: Expression of Glioblastoma Molecular Markers and Sensitivity to Innate Immune Peptides LL-37 and Protegrin-1 as Predictors of Chemotherapy Response

Stress Level in Parents with Premature Children Hospitalized in the Neonatal Intensive Care Unit in Hospital del Niño Dr. José Renán Esquivel During the Month of July 2022
type: item
description: A premature birth is an unexpected event for the parents, generating fear, anxiety and guilt, due to the culmination of the pregnancy and the condition of the baby. mothers with a premature child are three times more likely to have postpartum depression. Advances in technology have increased the chances of survival in premature infants, but they are prone to complications in the medium and long term. Materials and methods: An observational, descriptive study was carried out, applying a survey to 52 parents with premature infants less than or equal to 36 weeks of gestational age (SEG), who remained 7 or more days hospitalized in the Neonatal Intensive Care Unit (NICU). in the Neonatology Unit of the Dr. José Renán Esquivel Children’s Hospital, during the month of July 2022, transferred from the Santo Tomás Hospital. Results: According to the results of our studies, 69.2% of parents perceived themselves as not at all to slightly stressed, but when subdividing the scale into extra and intrapersonal stress levels, in the latter they had a moderate to extremely stressful level of stress. in 75%, therefore, 94.2% want to have a support group. Conclusion: It is essential for parents to have a support group.
subject: Articles
  topic: section
creator: Dr. Dra. Mariam Cano Amores
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2023-10-27
publication date: 2023-10-27
starting page: 27
ending page: 35

Virtual Autism and the Influence of Screens on Children’s Development
type: item
description: The growing abusive use of screens, such as smartphones, tablets and computers, has increased during and after the pandemic, raising concerns about its impact on children’s healthy development. This scenario is a concern in contemporary society, especially when evaluating its potential impact on children. This article addresses the implications of excessive screen use on child development, including its relationship with Autism Spectrum Disorder (ASD). Excessive time spent on electronic devices has been linked to negative effects on social skills. Additionally, intensive screen use can delay language development, negatively affecting communication skills in children aged 6 to 24 months. Furthermore, excessive use of screens can impair cognitive abilities, such as attention, memory and executive function, and also presents problems related to sleep, due to exposure to blue light that affects the production of melatonin, a sleep-regulating hormone. The findings suggest that excessive screen use can lead to changes in the development of the prefrontal cortex, an area crucial for executive functions. In the context of ASD, excessive screen use can worsen symptoms, including sensory sensitivity, sensory overload, stereotypical behaviors, and attention disorders. To promote healthy screen use, it is essential that parents establish appropriate limits, monitor the content accessed and encourage physical, social and educational activities outside the digital environment, in addition to seeking professional guidance with individualized assessment and the development of balanced strategies to the use of screens, ensuring the general well-being of children in their cognitive and social development. Considering that, although screens offer educational opportunities, their use must be balanced with face-to-face social interactions, which are fundamental for the healthy development of children.
subject: Articles
  topic: section
subject: screens. human development. autism. social skills
  topic: keywords
creator: Mariana Ramos
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2023-10-27
publication date: 2023-10-27
starting page: 7
ending page: 13

Medical Women’s Mental Health Factors During the COVID-19 Pandemic
type: item
description: The article is devoted to the study of the fear level of death in young nurses and senior students of medical school, and the role of tolerance to uncertainty in the development of fear of death. A study of 150 respondents was carried out: 73 people are nurses and paramedics, 72 are medical school students, senior courses. Students underwent practical training in hospitals, but were not directly involved in work with patients with COVID-19. The following methods were chosen: & quot; Fear of Death Scale & quot; by J. Boyar, Templer’s Death Anxiety Scale, method & quot; Inclination to suicidal behavior" by T. N. Razuvaev. also the questionnaire & quot; the Multiple Stimulus Types Ambiguity Tolerance Scale-II (MSTAT-II) by McLain in the adaptation of Osin. Women physicians who work directly in hospitals have a higher level of fear of death, but lower suicidal risks than students of medical specialties. Intolerance to uncertainty enhances individual manifestations of fear of death and suicidal risk.
subject: Articles
  topic: section
subject: COVID-19
  topic: keywords
subject: fear of death
  topic: keywords
subject: medical women
  topic: keywords
subject: Suicide
  topic: keywords
subject: tolerance
  topic: keywords
creator: Andrii Trofimov
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2023-11-15
publication date: 2023-11-15
starting page: 41
ending page: 47

https://journalspress.uk/index.php/LJMHR/article/view/1961
type: item
title: Breast Cancer in Argentina. Surrogate Parameters, Instead of the Genetic Profile, for Recurrence Risk Evaluation Inearly Stages,Estrogenreceptor-Positive, Her2-Neu Negative, Lymph Node-Negative” Cases in A Middle – Income Country.
description: Background. BreastCancer (BC)is the main cause of death and disability among women in low- and middle-income (MIC) countries like Argentina. In BCthe study of genic profile of cancer has been encouraged. Implementation of the multigene panels assay has led to a change in the manner in which chemotherapy is utilized mainly in patients with, early stage, estrogen receptor (ER)-positive, Her2-neu negative, lymph node-negativeBC. Unfortunately, all these tests are expensive. Given the potential savings in cost, algorithms have been proposed to predict Oncotype DX recurrence score (ODX RS) using commonly acquired clinical and histopathologic variables designated as subrogateparameters (SP).Materials and Methods. We evaluate the possibility, in a MIC country, of having the necessary data from the normally required report of the BC, in order to apply some of the ten (10) selected published algorithms offered as alternatives to ODXRS. From 1832 (stage I to IV) BC cases reported, between 2012 and 2015, a subset of 706 (38,5%) early stages “ER (+) / HER2 (-) / lymph node-negative” BC, was identified and analyzed. An online search and selection of published scientific research on same thematic, from 2010 onwards, was carried out.
subject: Articles
  topic: section
creator: Dr. Roberto Meiss,
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2024-01-10
publication date: 2024-01-10
starting page: 13
ending page: 22

A Comparison of Logistic Regression, Modified Logistic Regression and Naïve Bayes Models for Classifying HIV Viral load Suppression: The Case of Zombo District in Uganda
type: item
description: Purpose:To enhance the performance of the logistic regression by integrating step-wise procedures and henceforth compare and evaluate its performance with the Logistic regression and Naïve Bayes in classifying HIV viral load suppression (VLS). Methods:Models for classifying VLS were built using Logistic regression, modified logistic regression and Naïve Bayes classifiers. Accuracy, balanced accuracy and the area under the receiver operating characteristics curve (AUC) were the key performance metrics used to evaluate the generalizability of the various classifiers. Results:The modified logistic regression model trained on fewer predictor attributes achieved an accuracy of 84.9%, a balanced accuracy of 83.8% and an AUC of 92.6%. The traditional logistic regression model trained on a full set of predictor attributes achieved an accuracy of 84.9%, a balanced accuracy of 83.6% and an AUC of 92.5% whereas the naïve Bayes model achieved an accuracy of 81.6%, a balanced accuracy of 80.5% and AUC of 89.4%. Conclusion:The modified logistic regression model outperformed the traditional logistic regression and naïve Bayes models on account of recording higher balanced accuracy and AUC values of 83.8% and 92.6% respectively albeit with fewer predictor attributes. Hence integrating step-wise regression procedures in the traditional logistic regression model can enhance its classification performance leading to better predictions.
subject: Articles
  topic: section
subject: classification
  topic: keywords
subject: comparison
  topic: keywords
subject: logistic
  topic: keywords
subject: modified
  topic: keywords
subject: naïve bayes
  topic: keywords
subject: viral load suppression.
  topic: keywords
creator: Dr. Francis Fuller Bbosa
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2024-01-10
publication date: 2024-01-10
starting page: 23
ending page: 34

Motivation and Awareness Campaign: Institutional Evaluation of Facultade São Francisco De Assis
type: item
description: The quality of higher education is a topic of great relevance, as it is directly linked to the formation of qualified professionals for the exercise of their roles. To assess the quality of higher education, the Ministry of Education established parameters and implemented various evaluation instruments. The publication of Law 10.861/2004 systematized these assessments, highlighting the need for an in-depth study of the system and the active participation of the academic community in this process. The specific objective was to apply new evaluation instruments following a motivation and awareness campaign, assessing the new participation rates. The research was qualitative and quantitative, using a case study with document analysis. In the data discussion analysis, a comparative method was used to address the specific objective. The legislation from INEP and MEC provided the theoretical foundation for this investigation. In the final considerations, it was found that continuous mobilization and awareness efforts, through effective campaigns, enhance the understanding of the topic and contribute to improving the teaching and learning process, as well as promoting improvements in institutional infrastructure.
subject: Articles
  topic: section
creator: Dr. Elisiane Alves Fernandes
rights: Copyright (c) 2024 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2024-11-25
publication date: 2024-11-25
starting page: 47
ending page: 62

Impact of the Transplant Acceleration Program (PAT-MA) Phase I on Transplant Indicators in Maranhão, Brazil: A Retrospective Study
type: item
description: Introduction: In the context of public health, the efficiency of transplant programs is crucial to improving outcomes for patients on waiting lists. This study evaluated the impact of implementing the Transplant Acceleration Program (PAT-MA) at the Transplant Center of Maranhão, Brazil. Objectives: The aim of this study was to assess the impact of PAT-MA implementation on key performance indicators of the Maranhão Transplant Center, with a focus on improving the organization and effectiveness of the regional transplant system through structured management methodology. Methods: We conducted a retrospective observational study analyzing data from the Maranhão Transplant Center before and after the first phase of PAT-MA as a quality improvement initiative, comparing the years 2022 and 2023. The indicators collected included: number of transplants performed, waiting list size, notifications per million population, effective donors per million, organ transplants per million, corneal transplants per million, and number of active CIHDOTTs and OPOs. Results: Following PAT-MA implementation, there was a reduction in the family refusal rate (from 67% to 63%), a decrease in the rate of cardiac arrests before procurement completion (from 28% to 26%), an increase in notifications per million (from 172 [24/million] to 327 [46/million]), effective donors per million (from 12 [1.7/million] to 28 [3.9/million]), organ transplants per million (from 27 [3.9/million] to 62 [8.7/million]), corneal transplants per million (from 133 [18.6/million] to 255 [35/million]), and number of active CIHDOTTs and OPOs (from 3/0 to 10/1). These findings demonstrate marked growth and improvement in the regional transplant system. Conclusion: This study demonstrates that the implementation of the Transplant Acceleration Program (PAT-MA) had a positive impact on key performance indicators at the Maranhão Transplant Center. The results underscore the importance of strategic management approaches to optim…
subject: Articles
  topic: section
subject: brazil
  topic: keywords
subject: health systems
  topic: keywords
subject: management program
  topic: keywords
subject: Maranhão
  topic: keywords
subject: organ transplantation
  topic: keywords
subject: PAT-MA
  topic: keywords
subject: Quality improvement
  topic: keywords
creator: Dr. Luciana Sousa Silva
rights: Copyright (c) 2025 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2025-08-20
publication date: 2025-08-20
starting page: 71
ending page: 72

Neurological Manifestation of Chikungunya Virus and its Implication in the Pathogenesis of Guillain-Barré Syndrome: A Systematic Review of Clinical and Mechanistic Evidence
type: item
description: Chikungunya virus (CHIKV) infection has been linked to severe neurological outcomes, notably Guillain-Barré Syndrome (GBS). This systematic review highlights clinical and mechanistic evidence associating CHIKV with autoimmune polyradiculoneuropathies. Findings reveal the virus’s neurotropism and support its role as a triggering factor for GBS. Despite methodological heterogeneity among studies, the evidence underscores important implications for diagnosis, clinical surveillance, and patient management. Deeper understanding of this relationship is essential to improve preventive and therapeutic health strategies.
subject: Articles
  topic: section
subject: Arboviruses.
  topic: keywords
subject: Chikungunya
  topic: keywords
subject: guillain barre syndrome
  topic: keywords
subject: Peripheral neuropathies
  topic: keywords
creator: Dr. Thales Lgnacio Colina De Oliveira
rights: Copyright (c) 2025 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2025-11-14
publication date: 2025-11-14
starting page: 41
ending page: 52

Virtual Autism and the Influence of Screens on Children’s Development
type: item
description: The growing abusive use of screens, such as smartphones, tablets and computers, has increased during and after the pandemic, raising concerns about its impact on children’s healthy development. This scenario is a concern in contemporary society, especially when evaluating its potential impact on children. This article addresses the implications of excessive screen use on child development, including its relationship with Autism Spectrum Disorder (ASD). Excessive time spent on electronic devices has been linked to negative effects on social skills. Additionally, intensive screen use can delay language development, negatively affecting communication skills in children aged 6 to 24 months. Furthermore, excessive use of screens can impair cognitive abilities, such as attention, memory and executive function, and also presents problems related to sleep, due to exposure to blue light that affects the production of melatonin, a sleep-regulating hormone. The findings suggest that excessive screen use can lead to changes in the development of the prefrontal cortex, an area crucial for executive functions. In the context of ASD, excessive screen use can worsen symptoms, including sensory sensitivity, sensory overload, stereotypical behaviors, and attention disorders. To promote healthy screen use, it is essential that parents establish appropriate limits, monitor the content accessed and encourage physical, social and educational activities outside the digital environment, in addition to seeking professional guidance with individualized assessment and the development of balanced strategies to the use of screens, ensuring the general well-being of children in their cognitive and social development. Considering that, although screens offer educational opportunities, their use must be balanced with face-to-face social interactions, which are fundamental for the healthy development of children.
subject: Articles
  topic: section
subject: screens. human development. autism. social skills
  topic: keywords
creator: Mariana Ramos
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2023-10-27
publication date: 2023-10-27
starting page: 7
ending page: 13

Stress Level in Parents with Premature Children Hospitalized in the Neonatal Intensive Care Unit in Hospital del Niño Dr. José Renán Esquivel During the Month of July 2022
type: item
description: A premature birth is an unexpected event for the parents, generating fear, anxiety and guilt, due to the culmination of the pregnancy and the condition of the baby. mothers with a premature child are three times more likely to have postpartum depression. Advances in technology have increased the chances of survival in premature infants, but they are prone to complications in the medium and long term. Materials and methods: An observational, descriptive study was carried out, applying a survey to 52 parents with premature infants less than or equal to 36 weeks of gestational age (SEG), who remained 7 or more days hospitalized in the Neonatal Intensive Care Unit (NICU). in the Neonatology Unit of the Dr. José Renán Esquivel Children’s Hospital, during the month of July 2022, transferred from the Santo Tomás Hospital. Results: According to the results of our studies, 69.2% of parents perceived themselves as not at all to slightly stressed, but when subdividing the scale into extra and intrapersonal stress levels, in the latter they had a moderate to extremely stressful level of stress. in 75%, therefore, 94.2% want to have a support group. Conclusion: It is essential for parents to have a support group.
subject: Articles
  topic: section
creator: Dr. Dra. Mariam Cano Amores
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2023-10-27
publication date: 2023-10-27
starting page: 27
ending page: 35

Medical Women’s Mental Health Factors During the COVID-19 Pandemic
type: item
description: The article is devoted to the study of the fear level of death in young nurses and senior students of medical school, and the role of tolerance to uncertainty in the development of fear of death. A study of 150 respondents was carried out: 73 people are nurses and paramedics, 72 are medical school students, senior courses. Students underwent practical training in hospitals, but were not directly involved in work with patients with COVID-19. The following methods were chosen: & quot; Fear of Death Scale & quot; by J. Boyar, Templer’s Death Anxiety Scale, method & quot; Inclination to suicidal behavior" by T. N. Razuvaev. also the questionnaire & quot; the Multiple Stimulus Types Ambiguity Tolerance Scale-II (MSTAT-II) by McLain in the adaptation of Osin. Women physicians who work directly in hospitals have a higher level of fear of death, but lower suicidal risks than students of medical specialties. Intolerance to uncertainty enhances individual manifestations of fear of death and suicidal risk.
subject: Articles
  topic: section
subject: COVID-19
  topic: keywords
subject: fear of death
  topic: keywords
subject: medical women
  topic: keywords
subject: Suicide
  topic: keywords
subject: tolerance
  topic: keywords
creator: Andrii Trofimov
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2023-11-15
publication date: 2023-11-15
starting page: 41
ending page: 47

https://journalspress.uk/index.php/LJMHR/article/view/1912
type: item
title: Breast Cancer in Argentina. Surrogate Parameters, Instead of the Genetic Profile, for Recurrence Risk Evaluation Inearly Stages,Estrogenreceptor-Positive, Her2-Neu Negative, Lymph Node-Negative” Cases in A Middle – Income Country.
description: Background. BreastCancer (BC)is the main cause of death and disability among women in low- and middle-income (MIC) countries like Argentina. In BCthe study of genic profile of cancer has been encouraged. Implementation of the multigene panels assay has led to a change in the manner in which chemotherapy is utilized mainly in patients with, early stage, estrogen receptor (ER)-positive, Her2-neu negative, lymph node-negativeBC. Unfortunately, all these tests are expensive. Given the potential savings in cost, algorithms have been proposed to predict Oncotype DX recurrence score (ODX RS) using commonly acquired clinical and histopathologic variables designated as subrogateparameters (SP).Materials and Methods. We evaluate the possibility, in a MIC country, of having the necessary data from the normally required report of the BC, in order to apply some of the ten (10) selected published algorithms offered as alternatives to ODXRS. From 1832 (stage I to IV) BC cases reported, between 2012 and 2015, a subset of 706 (38,5%) early stages “ER (+) / HER2 (-) / lymph node-negative” BC, was identified and analyzed. An online search and selection of published scientific research on same thematic, from 2010 onwards, was carried out.
subject: Articles
  topic: section
creator: Dr. Roberto Meiss,
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2024-01-10
publication date: 2024-01-10
starting page: 13
ending page: 22

A Comparison of Logistic Regression, Modified Logistic Regression and Naïve Bayes Models for Classifying HIV Viral load Suppression: The Case of Zombo District in Uganda
type: item
description: Purpose:To enhance the performance of the logistic regression by integrating step-wise procedures and henceforth compare and evaluate its performance with the Logistic regression and Naïve Bayes in classifying HIV viral load suppression (VLS). Methods:Models for classifying VLS were built using Logistic regression, modified logistic regression and Naïve Bayes classifiers. Accuracy, balanced accuracy and the area under the receiver operating characteristics curve (AUC) were the key performance metrics used to evaluate the generalizability of the various classifiers. Results:The modified logistic regression model trained on fewer predictor attributes achieved an accuracy of 84.9%, a balanced accuracy of 83.8% and an AUC of 92.6%. The traditional logistic regression model trained on a full set of predictor attributes achieved an accuracy of 84.9%, a balanced accuracy of 83.6% and an AUC of 92.5% whereas the naïve Bayes model achieved an accuracy of 81.6%, a balanced accuracy of 80.5% and AUC of 89.4%. Conclusion:The modified logistic regression model outperformed the traditional logistic regression and naïve Bayes models on account of recording higher balanced accuracy and AUC values of 83.8% and 92.6% respectively albeit with fewer predictor attributes. Hence integrating step-wise regression procedures in the traditional logistic regression model can enhance its classification performance leading to better predictions.
subject: Articles
  topic: section
subject: classification
  topic: keywords
subject: comparison
  topic: keywords
subject: logistic
  topic: keywords
subject: modified
  topic: keywords
subject: naïve bayes
  topic: keywords
subject: viral load suppression.
  topic: keywords
creator: Dr. Francis Fuller Bbosa
rights: Copyright (c) 2023 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2024-01-10
publication date: 2024-01-10
starting page: 23
ending page: 34

Motivation and Awareness Campaign: Institutional Evaluation of Facultade São Francisco De Assis
type: item
description: The quality of higher education is a topic of great relevance, as it is directly linked to the formation of qualified professionals for the exercise of their roles. To assess the quality of higher education, the Ministry of Education established parameters and implemented various evaluation instruments. The publication of Law 10.861/2004 systematized these assessments, highlighting the need for an in-depth study of the system and the active participation of the academic community in this process. The specific objective was to apply new evaluation instruments following a motivation and awareness campaign, assessing the new participation rates. The research was qualitative and quantitative, using a case study with document analysis. In the data discussion analysis, a comparative method was used to address the specific objective. The legislation from INEP and MEC provided the theoretical foundation for this investigation. In the final considerations, it was found that continuous mobilization and awareness efforts, through effective campaigns, enhance the understanding of the topic and contribute to improving the teaching and learning process, as well as promoting improvements in institutional infrastructure.
subject: Articles
  topic: section
creator: Dr. Elisiane Alves Fernandes
rights: Copyright (c) 2024 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2024-11-25
publication date: 2024-11-25
starting page: 47
ending page: 62

Impact of the Transplant Acceleration Program (PAT-MA) Phase I on Transplant Indicators in Maranhão, Brazil: A Retrospective Study
type: item
description: Introduction: In the context of public health, the efficiency of transplant programs is crucial to improving outcomes for patients on waiting lists. This study evaluated the impact of implementing the Transplant Acceleration Program (PAT-MA) at the Transplant Center of Maranhão, Brazil. Objectives: The aim of this study was to assess the impact of PAT-MA implementation on key performance indicators of the Maranhão Transplant Center, with a focus on improving the organization and effectiveness of the regional transplant system through structured management methodology. Methods: We conducted a retrospective observational study analyzing data from the Maranhão Transplant Center before and after the first phase of PAT-MA as a quality improvement initiative, comparing the years 2022 and 2023. The indicators collected included: number of transplants performed, waiting list size, notifications per million population, effective donors per million, organ transplants per million, corneal transplants per million, and number of active CIHDOTTs and OPOs. Results: Following PAT-MA implementation, there was a reduction in the family refusal rate (from 67% to 63%), a decrease in the rate of cardiac arrests before procurement completion (from 28% to 26%), an increase in notifications per million (from 172 [24/million] to 327 [46/million]), effective donors per million (from 12 [1.7/million] to 28 [3.9/million]), organ transplants per million (from 27 [3.9/million] to 62 [8.7/million]), corneal transplants per million (from 133 [18.6/million] to 255 [35/million]), and number of active CIHDOTTs and OPOs (from 3/0 to 10/1). These findings demonstrate marked growth and improvement in the regional transplant system. Conclusion: This study demonstrates that the implementation of the Transplant Acceleration Program (PAT-MA) had a positive impact on key performance indicators at the Maranhão Transplant Center. The results underscore the importance of strategic management approaches to optim…
subject: Articles
  topic: section
subject: brazil
  topic: keywords
subject: health systems
  topic: keywords
subject: management program
  topic: keywords
subject: Maranhão
  topic: keywords
subject: organ transplantation
  topic: keywords
subject: PAT-MA
  topic: keywords
subject: Quality improvement
  topic: keywords
creator: Dr. Luciana Sousa Silva
rights: Copyright (c) 2025 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2025-08-20
publication date: 2025-08-20
starting page: 71
ending page: 72

Neurological Manifestation of Chikungunya Virus and its Implication in the Pathogenesis of Guillain-Barré Syndrome: A Systematic Review of Clinical and Mechanistic Evidence
type: item
description: Chikungunya virus (CHIKV) infection has been linked to severe neurological outcomes, notably Guillain-Barré Syndrome (GBS). This systematic review highlights clinical and mechanistic evidence associating CHIKV with autoimmune polyradiculoneuropathies. Findings reveal the virus’s neurotropism and support its role as a triggering factor for GBS. Despite methodological heterogeneity among studies, the evidence underscores important implications for diagnosis, clinical surveillance, and patient management. Deeper understanding of this relationship is essential to improve preventive and therapeutic health strategies.
subject: Articles
  topic: section
subject: Arboviruses.
  topic: keywords
subject: Chikungunya
  topic: keywords
subject: guillain barre syndrome
  topic: keywords
subject: Peripheral neuropathies
  topic: keywords
creator: Dr. Thales Lgnacio Colina De Oliveira
rights: Copyright (c) 2025 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2025-11-14
publication date: 2025-11-14
starting page: 41
ending page: 52

The Effect of Dietary Fiber on Glycemic Control in Patients with Type 2 Diabetes Mellitus Receiving Oral Hypoglycemic Therapy
type: item
description: Introduction: Nutritional recommendations for patients with T2DM from various global communities agree on the need to increase dietary fiber (DF) intake; however, there are currently no specific and unified recommendations regarding the recommended amount and type of DF. Studying the effect of DF on glycemic control in patients with T2DM may play an important role in refining intake recommendations and motivating patients to comply these recommendations. Objective of the Study: Evaluation of the effect of Nestlé OptiFibre DF on glycemic control parameters in patients with T2DM treated with combination hypoglycemic therapy with metformin plus dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) or with metformin plus sodium-glucose cotransporter type 2 inhibitors (SGLT2 inhibitors). Materials and Methods: The study included 80 patients with T2DM, with duration not more than 5 years, with HbA1c of not more than 7.5%, and BMI of 27–35 kg/m2, without severe comorbidity. All patients were treated with a combination of metformin and a DPP-4 inhibitor or metformin and an SGLT2 inhibitor. Forty patients comprised the Main Group, where patients received Nestlé OptiFibre DF, a partially hydrolyzed guar gum (PHGG), for 3 months according to the instructions for use. The other patients, who comprised the Control Group, underwent the same examinations as the patients in the Main Group as part of routine clinical practice over a period of 3 months. Changes over time in HbA1c, fasting plasma glucose, blood glucose self-monitoring data, and ambulatory blood glucose profile based on flash glucose monitoring (FGM, FreeStyle Libre, Abbott) were evaluated. Laboratory parameters were evaluated at baseline (2–3 days from the start of the study) and at the completion of the study (84 ± 3 days from the start of the study). A FGM sensor was also applied at Days 2–3 from the start of the study; the readings were obtained and evaluated after 14 days. Repeated FGM application was performed at …
subject: Articles
  topic: section
subject: Dietary fiber
  topic: keywords
subject: gut microbiota
  topic: keywords
subject: oral hypoglycemic therapy
  topic: keywords
subject: type 2 diabetes mellitus
  topic: keywords
creator: T. Yu. Demidova
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-06-17
publication date: 2026-06-17
starting page: 39
ending page: 53
doi: 10.34257/LJMHR226817UK

Diabetic Foot: A Multidisciplinary Approach to Limb Preservation
type: item
description: Diabetic foot is a major chronic complication of diabetes mellitus and represents a leading cause of hospitalisation, infection and non- traumatic lower limb amputation worldwide. The pathogenesis is multifactorial primarily involving peripheral neuropathy, peripheral arterial disease, impaired immunity and poor glycemic control which together predispose patients to ulceration and delayed wound healing. This review of literature aims to summarise current evidence regarding epidemiology, risk factors clinical evaluation and treatment strategies for diabetic foot disease. The literature consistently demonstrates that early identification of at-risk patients through routine screening and structured risk stratification significantly reduces ulcer occurrence. Management of established diabetic foot ulcers requires a multi-disciplinary approach combining glycemic control, infection management using culture guided antimicrobial therapy, regular wound debridement, appropriate wound dressings and appropriate offloading techniques.In patients with associated ischaemia, timely vascular assessment followed by endovascular or surgical revascularisation is critical for limb salvage. Advanced adjunctive therapies including negative pressure wound therapy, bioengineered skin substitutes and growth factor- based treatments have shown beneficial outcomes in selected cases. Overall, comprehensive preventive programs and standardised multidisciplinary treatment protocols remain essential for reducing amputation rates and improving functional outcomes in patients with diabetic foot disease.
subject: Articles
  topic: section
subject: diabetic foot
  topic: keywords
subject: management
  topic: keywords
subject: peripheral vascular disease.
  topic: keywords
subject: treatment
  topic: keywords
subject: ulcer
  topic: keywords
creator: Amol Amonkar
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-06-17
publication date: 2026-06-17
starting page: 1
ending page: 9
doi: 10.34257/LJMHR226766UK

Evaluating Midwives’ Knowledge and Attitudes Regarding Pre-Eclampsia Management at Presbyterian Hospital
type: item
description: Background: Pre-eclampsia is a major contributor to maternal and perinatal morbidity and mortality globally and in Ghana. Midwives play a critical role in the early detection and management; however, their knowledge, attitudes, and the challenges they encounter influence the quality of care. Methodology/Principal Findings: A descriptive cross-sectional study was conducted among 50 midwives using a structured self-administered questionnaire. Data were analyzed using SPSS version 26. Descriptive statistics summarized demographic characteristics, knowledge, attitudes, barriers, and recommendations. Chi-square tests and logistic regression examined associations between demographic variables and knowledge/attitude levels. The majority of respondents were aged 20–39 years (70.0%), with 54.0% having 1–3 years of experience, and 86.0% had received prior training in pre-eclampsia management. Knowledge was generally high, with 88.0% recognizing hallmark symptoms and 84.0% identifying magnesium sulfate as the first-line anticonvulsant. Attitudes were positive; 68.0% strongly agreed that pre-eclampsia training should be mandatory. Key barriers included limited patient awareness (86.0%), understaffing (70.0%), and inadequate diagnostic tools (58.0%). Years of experience were significantly associated with knowledge level (chi-square = 19.470, p=0.003), while logistic regression showed work unit as a significant predictor of knowledge level (p = 0.037). Conclusion: Midwives exhibited good knowledge and positive attitudes toward pre-eclampsia management, though systemic barriers constrain effective care. Strengthening in-service training, improving diagnostic and therapeutic resources, and enhancing patient education are recommended to optimize outcomes.
subject: Articles
  topic: section
subject: Attitudes
  topic: keywords
subject: barriers
  topic: keywords
subject: Ghana.
  topic: keywords
subject: knowledge
  topic: keywords
subject: Midwives
  topic: keywords
subject: Pre-eclampsia (PE)
  topic: keywords
creator: Dr. Prince Yaw Boakye
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-06-17
publication date: 2026-06-17
starting page: 28
ending page: 38
doi: 10.34257/LJMHR226192UK

Calcium Hydroxide Induced Apexification in an Immature, Non-Vital Permanent Tooth – A Case Report
type: item
description: The purpose of the present manuscript is to show case successful formation of apical barrier in an immature young permanent tooth following dental trauma using calcium hydroxide as an intra-canal medicament. Following 9 month follow-up, apical barrier formation and absence of periapical radiolucency was evident on intraoral periapical radiographic examination with clinical absence of signs and symptoms. This case report strongly confirms that calcium hydroxide still remains as age old, gold standard medicament in inducing apical barrier formation thereby facilitating a dental practitioner to perform smooth root canal treatment.
subject: Articles
  topic: section
subject: apexification
  topic: keywords
subject: apical barrier formation
  topic: keywords
subject: blunder bus canal
  topic: keywords
subject: calcium hydroxide
  topic: keywords
subject: immature
  topic: keywords
subject: non-vital tooth
  topic: keywords
creator: Nagaveni NB
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-06-17
publication date: 2026-06-17
starting page: 18
ending page: 24
doi: 10.34257/LJMHR226575UK

Effectiveness of Recombinant Enzymes in Cellulite Treatment: A Case Report
type: item
description: Cellulite is a common aesthetic concern that may significantly impact on individuals’ self-image and quality of life. Despite being a non-threatening condition, it may have a negative effect on the psychological well-being of affected individuals. This condition is multifactorial and involves several physiopathology pathways. The role of enzymes in the management of cellulite is a novel approach, particularly lipase and collagenase, which play key roles in adipocyte size reduction and collagen degradation, respectively. The potential of high-molecular-weight hyaluronic acid to promote tissue repair and regeneration is also highlighted. Our case report describes the effectiveness of an association of recombinant enzymes and high-molecular-weight hyaluronic acid by reducing cellulite manifestations in a patient, with a history of multiple unsuccessful treatments, showing visible improvements from the initial treatment session. The importance of understanding the complex physiopathology of cellulite and choosing a targeted approach is emphasized.
subject: Articles
  topic: section
subject: cellulite
  topic: keywords
subject: collagenase
  topic: keywords
subject: hyaluronic acid
  topic: keywords
subject: lipase
  topic: keywords
subject: lyase
  topic: keywords
subject: recombinant enzymes
  topic: keywords
creator: Jorge A. López Berroa
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-06-17
publication date: 2026-06-17
starting page: 25
ending page: 27
doi: 10.34257/LJMHR226395UK

The Paradox of Airway Closure: From Protection to Pathology
type: item
description: Airway closure, first recognized by Laennec and later quantified in studies by Dollfuss, Hedenstierna and Hughes, represents a physiological phenomenon with far-reaching clinical consequences. While often overlooked in critical care, its role in promoting atelectasis, impaired gas exchange, and ventilator-induced lung injury is well established. The present narrative review revisits the fundamental physiology of airway closure, its exacerbation in anaesthesia and obesity, and its near-universality in mechanically ventilated ARDS patients. A reinterpretation of pleural pressure data from landmark studies, suggests that airway closure may be far more prevalent than currently appreciated. Strategies such as optimal PEEP and avoidance of high oxygen fractions are discussed, with emphasis on the urgent need for better integration of airway closure physiology into clinical practice. This article re-examines how positive airway pressure in combination with elevated intrathoracic pressure — the inevitable companion of positive pressure ventilation — underlies many of the adverse effects attributed to modern mechanical ventilation. By contrast, negative pressure ventilation, long abandoned, may offer physiological advantages worth reconsidering. The question we must now ask is: could a return to negative extra-thoracic pressure — or a hybrid model — prevent the very complications we have come to accept as inevitable?
subject: Articles
  topic: section
subject: airway closure
  topic: keywords
subject: airway resistance
  topic: keywords
subject: atelectasis
  topic: keywords
subject: intra-thoracic pressure
  topic: keywords
subject: mechanical ventilation
  topic: keywords
subject: negative pressure ventilation
  topic: keywords
subject: pleural pressure
  topic: keywords
subject: positive pressure ventilation
  topic: keywords
subject: ventilator induced lung injury
  topic: keywords
creator: Jan van Egmond
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-06-17
publication date: 2026-06-17
starting page: 10
ending page: 17
doi: 10.34257/LJMHR226753UK

Innovative Wound Dressings and Emerging Technologies for Wound Treatment: Trends and Perspectives – A Review
type: item
description: Background/Objectives: Wound treatment has undergone significant advances with the development of dressings and therapies that provide not only simple protective coverage but also actively promote tissue regeneration. This work addresses the classification of dressings, ranging from primary and secondary types to cutting-edge technologies, including bioactive, innovative, 3D-printed, and nanotechnological dressings. Methods: A structured narrative literature review was conducted by searching major health, nursing, and wound care databases major health, nursing, and wound care databases, complemented by specialized sources. Results: The review indicates that auxiliary therapies, such as stem cells, growth factors, and cold plasma, are predominantly explored as adjunctive approaches alongside advanced wound dressings, with the literature reporting potential benefits in accelerating healing, especially in complex and chronic wound settings. It also highlights the primary challenges to implementing these approaches, including high production costs, a shortage of trained professionals, limited robust, long-term clinical studies, and regulatory hurdles. Additionally, the environmental impacts of dressing production and disposal were addressed, highlighting the role of biopolymers and nanotechnology as sustainable and ef icient alternatives to traditional methods. Conclusions: Despite current limitations, future prospects remain promising, with an emphasis on personalized medicine, intelligent monitoring systems, and bioengineering, underscoring the need for more in-depth research and clinical validation to consolidate these innovations in wound care practice.
subject: Articles
  topic: section
subject: biomaterials
  topic: keywords
subject: biomedical innovations
  topic: keywords
subject: biopolymers
  topic: keywords
subject: clinical challenges
  topic: keywords
subject: drug delivery systems
  topic: keywords
subject: healthcare technology.
  topic: keywords
subject: sustainable wound care
  topic: keywords
subject: wound management
  topic: keywords
creator: Gil Sander Gama
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-05-05
publication date: 2026-05-05
starting page: 1
ending page: 21
doi: 10.34257/LJMHR226053UK

Cross-Scale Analogies between Astrophysics and Human Biology: Conceptual and Technological Parallels in the Study of Complex Systems
type: item
description: Over the last few decades, our uderstanding of both the universe and the microscopic world has progressed remarkably. The rise of modern science, bolstered by the evolution of observational instruments, such as the Hubble and James Webb telescopes for cosmic exploration, and next-generation microscopes for the study of living organisms, has led to significant discoveries. Since the invention of the telescope, astronomers have progressively unveiled the structure and dynamics of the universe, establishing the foundations of astrophysics. In parallel, advances in microscopy have enabled the exploration of the infinitely small, revealing the fundamental mechanisms of the human body and laying the groundwork for physiology and molecular biology. Nanotechnology has further refined telescopes and revolutionized medical care, particularly in targeted therapy and regenerative medicine. At first glance, the scales of magnitude inherent to the biological world and those governing the observable universe appear fundamentally disjointed. On one hand, molecular biology explores a microscopic universe: cells, proteins, and subcellular structures, where distances are measured in nanometers or even smaller fractions, expressed in negative powers. On the other, astrophysics deals with objects and structures whose dimensions span light-years, parsecs, and megaparsecs, corresponding to extreme positive orders of magnitude. The systemic complexity of the human organism, much like cosmological structures, simultaneously engages the cognitive, metaphysical, and rational dimensions of the observer. Iconographic data from microscopy and astronomy transcend their purely heuristic function to reveal an intrinsic aesthetic capable of catalyzing intellectual inquiry. These representations facilitate the identification of structural correlations that go beyond simple formal analogy. The emergence of these morphological convergences between radically distinct scales raises a fundamental question…
subject: Articles
  topic: section
subject: astrophysics
  topic: keywords
subject: biological systems
  topic: keywords
subject: complex systems
  topic: keywords
subject: cosmic structures
  topic: keywords
subject: Human Physiology
  topic: keywords
subject: interdisciplinary science
  topic: keywords
subject: microscopy
  topic: keywords
subject: Nanotechnology
  topic: keywords
subject: scientific analogies
  topic: keywords
subject: telescopes
  topic: keywords
creator: Dr. EL GALIOU. M
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-05-05
publication date: 2026-05-05
starting page: 29
ending page: 37
doi: 10.34257/LJMHR226152UK

Pharmacotherapy of Heart Failure in Infants with Congenital Heart Disease
type: item
description: Every second patient who dies from congenital heart disease is an infant with heart failure. However, infants were de facto excluded from the US Carvedilol trial and PANORAMA HF trial (Sacubitril/Valsartan), probably due to their high mortality risk. Despite the negative results of the US Enalapril trial in infants with univentricular hearts, ACE inhibitors are further recommended in the guidelines. Propranolol is the only drug that has been successful in two prospective randomized trials but was not recommended in the guidelines. This review discusses the dif erences between myocardial heart failure and congestive circulatory failure in infants with congenital heart disease that do not benefit from vasodilators but from beta-blockers that significantly improve clinical symptoms, neurohormonal activation and heart rate variability. The case of a non-invasive monitoring of heart rate variability, blood pressure and oxygen saturation of an infant with Down syndrome and complete atrioventricular septal defect visualize cardiac decompensation after enalapril and the benefits of beta-blocker treatment.
subject: Articles
  topic: section
subject: ACE inhibitor
  topic: keywords
subject: beta blocker
  topic: keywords
subject: heart failure
  topic: keywords
subject: heart rate variability
  topic: keywords
subject: Keywords: congenital heart disease
  topic: keywords
subject: pharmacotherapy
  topic: keywords
creator: Dr. Reiner Buchhorn
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-05-05
publication date: 2026-05-05
starting page: 22
ending page: 28
doi: 10.34257/LJMHR226113UK

Is Primary Hypothyroidism Truly Primary? A Systems-based Reframing of Thyroid Dysfunction
type: item
description: Primary hypothyroidism is traditionally defined as intrinsic failure of the thyroid gland, most commonly attributed to autoimmune destruction or idiopathic atrophy. While this framework has guided diagnosis and treatment for decades, it may oversimplify the complex neuroendocrine, immune, and metabolic interactions that precede overt thyroid dysfunction. Emerging evidence suggests that immune dysregulation, chronic inflammation, hypothalamic–pituitary–adrenal (HPA) axis activation, nutrient insufficiency, mitochondrial dysfunction, and altered thyroid hormone signaling frequently predate biochemical thyroid failure. In this context, thyroid hypofunction may represent a downstream adaptive response rather than a primary isolated glandular disorder. This narrative review reexamines the concept of “primary” hypothyroidism through an integrative systems-based lens, highlighting mechanisms of functional hypothyroidism, impaired peripheral hormone conversion, thyroid hormone resistance, and immune- mediated loss of tolerance. Clinical implications include recognition of patients who remain symptomatic despite normalization of thyroid-stimulating hormone levels and the limitations of levothyroxine monotherapy in select populations. Reframing hypothyroidism as a secondary manifestation of upstream physiologic stressors may improve diagnostic precision and support more personalized therapeutic strategies.
subject: Articles
  topic: section
subject: Autoimmune thyroiditis
  topic: keywords
subject: Deiodinases
  topic: keywords
subject: Functional hypothyroidism
  topic: keywords
subject: Levothyroxine therapy
  topic: keywords
subject: Non-thyroidal illness syndrome
  topic: keywords
subject: Precision endocrinology
  topic: keywords
subject: Primary hypothyroidism
  topic: keywords
subject: Thyroid hormone signaling
  topic: keywords
creator: Dr. Angela D Mazza
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-05-05
publication date: 2026-05-05
starting page: 38
ending page: 50
doi: 10.34257/LJMHR226181UK

Effectiveness and Safety of Treatment of Double Chin with Combined Enzymatic Therapy
type: item
description: Cellulite is a common aesthetic concern that may significantly impact on individuals’ self-image and quality of life. Despite being a non-threatening condition, it may have a negative effect on the psychological well-being of affected individuals. This condition is multifactorial and involves several physiopathology pathways. The role of enzymes in the management of cellulite is a novel approach, particularly lipase and collagenase, which play key roles in adipocyte size reduction and collagen degradation, respectively. The potential of high-molecular-weight hyaluronic acid to promote tissue repair and regeneration is also highlighted. Our case report describes the effectiveness of an association of recombinant enzymes and high-molecular-weight hyaluronic acid by reducing cellulite manifestations in a patient, with a history of multiple unsuccessful treatments, showing visible improvements from the initial treatment session. The importance of understanding the complex physiopathology of cellulite and choosing a targeted approach is emphasized.
subject: Articles
  topic: section
subject: collagenase
  topic: keywords
subject: combined enzymatic treatment
  topic: keywords
subject: double chin
  topic: keywords
subject: hyaluronic acid
  topic: keywords
subject: lipase
  topic: keywords
subject: lyase
  topic: keywords
creator: Dr. Jorge Lopez Berroa
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-02-28
publication date: 2026-02-28
starting page: 27
ending page: 34
doi: 10.34257/LJMHR225763UK

Evolution of EU Legislation governing the presence of undesirable substances in animal feeds
type: item
description: The legislative framework for undesirable substances in EU territory is explained at first with parallel commenting on the political dimension involved in this issue as regards the sector of animal feeding. Then, a brief account on developments of Community legislation in this field is given, with paying particular emphasis on the delicate subject of “dilution principle”. In turn, reference is made to methods available for the analysis of undesirable substances in feeds. Furthermore, the article focuses on two groups of undesirable substances, i.e. firstly mycotoxins, where reference is made to legislative developments in this issue as well as prevention measures, and secondly, dioxins where a look is thrown to the historical background in this subject, while focusing on the dioxin episode in Belgium but also on subsequent findings. The legislative tools to confront problems of undesirable substances presence in the sector of animal nutrition is discussed, concluding with the importance of environmental dimension. Finally, reference is made to developments in Community Legislation for dioxins and mycotoxins during the last decade.
subject: Articles
  topic: section
subject: animal feeds
  topic: keywords
subject: dioxins
  topic: keywords
subject: EU legislation
  topic: keywords
subject: mycotoxins.
  topic: keywords
subject: undesirable substances
  topic: keywords
creator: Dr. Pantelis E. Zoiopoulos
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-02-28
publication date: 2026-02-28
starting page: 35
ending page: 49
doi: 10.34257/LJMHR225970UK

Drug Poisoning: Toxicological Emergency
type: item
description: The use of medications in conventional dosages guarantees their mechanism of action and provides the expected biological effects. Clinical trials and research on substances approved by the national health agency justify their clinical efficacy and demonstrate the risk-benefit of the medication, but they also contain some information on the toxic effects on the body when used in doses above the recommended. A bibliographic review was conducted targeting some classes of medications, such as antipsychotics, SSRI antidepressants (serotonin reuptake inhibitors), tricyclic and tetracyclic antidepressants, lithium, benzodiazepines, nonsteroidal anti-inflammatory drugs (NSAIDs), anticholinergics, digitalis, opiates, opioids and thyroid hormone, to update knowledge on drug poisoning protocols established by other institutions that are references in the subject, making it possible to identify symptoms and define treatments for these cases. Thus, in drug poisoning, irreversible effects can be observed in the short and long term, and even death if not treated appropriately. The available protocols used in reference centers and units for this type of care describe the identification of possible associated toxic syndromes, symptom management, symptomatic treatment and the antidote that can be used. Therefore, clinical research and pharmacovigilance contribute to the elucidation and understanding of toxicological effects, being an updated source based on the availability of information that occurs in hospital practice.
subject: Articles
  topic: section
subject: drug poisoning
  topic: keywords
subject: overdose
  topic: keywords
subject: toxicological emergency
  topic: keywords
creator: Dr. Guilherme Campos Da Luz
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-02-28
publication date: 2026-02-28
starting page: 1
ending page: 13

Expression of Glioblastoma Molecular Markers and Sensitivity to Innate Immune Peptides LL-37 and Protegrin-1 as Predictors of Chemotherapy Response
type: item
description: Glioblastoma (GBM) is one of the most aggressive and difficult-to-treat tumors in humans. The low efficacy of treatment is due to the molecular and cellular heterogeneity of the tumor, as well as disruption of biochemical mechanisms of the innate immune system, including peptides such as cathelicidin LL-37 and protegrin-1 (PG-1). The objective: to establish the effect of the combined use of LL-37, PG-1 and chemotherapy drugs on the expression of p53, GFAP, ATRX, Ki-67, TF, PDPN and EGFR proteins in GBM patient cell cultures, as well as their relationship to overall survival (OS) and life expectancy (LE) of patients. Materials and Methods: Cells were isolated from GBM biopsies obtained from patients (n = 30) and grown under standard conditions for 2 days. The cells were treated with different doses of the following chemotherapy drugs: temozolomide (TMZ), doxorubicin (DOX), carboplatin (CARB), cisplatin (CIS), etoposide (ETO) as well as peptides LL-37, PG-1, to determine the 50% inhibitory concentration (IC50) using the MTT assay. The expression of p53, isocitrate dehydrogenase-1 (IDH1), glial fibrillary acidic protein (GFAP), ATP helicase chromatin (ATRX), proliferation antigen (Ki-67), transferrin (TF), podoplanin (PDPN), and epidermal growth factor receptor (EGFR) proteins in GBM cells analyzed using immunohistochemical (ICH) staining with specific antibodies. Associations between these proteins and OS were analyzed using GraphPad Prism 8.0 software. Results: Statistically significant correlations were found between the expression of TF (r= -0.556, p=0.04), EGFR (r=0.799, p=0.03) and Ki-67 (r= 0.651 p=0.002) and TF (r=-0.899, p=0.004) in GBM cells and the IC50 values of LL-37, PG-1 respectively. The low IC50 value of LL-37 (less than 7 μM) and the high expression of p53 protein (20%, 12 vs 6.5 months, p=0.0037), GFAP (40%, 12 vs 9 months, p=0.0019) were associated with a longer life expectancy for the patients. In contrast, low sensitivity of GBM cells to LL-37 (hi…
subject: Articles
  topic: section
subject: ATRX
  topic: keywords
subject: Chemotherapy
  topic: keywords
subject: EGFR
  topic: keywords
subject: GFAP
  topic: keywords
subject: glioblastoma
  topic: keywords
subject: innate immune peptides LL-37
  topic: keywords
subject: Ki-67
  topic: keywords
subject: life expectancy
  topic: keywords
subject: P53
  topic: keywords
subject: PG-1
  topic: keywords
creator: Dr. Alexander N. Chernov
rights: Copyright (c) 2026 Authors and Global Journals Private Limited http://creativecommons.org/licenses/by/4.0/
date: 2026-02-28
publication date: 2026-02-28
starting page: 15
ending page: 25