Epidemiological Factors Affecting Post COVID-19 Acute Invasive Fungal Rhino-Sinusitis Incidence and Prognosis
Keywords:
Risk factors, Surgery, mortality, Trauma, Chest, Wound., disease incidence, Coronavirus Disease-19, Acute Invasive Fungal, RhinosinusitisAbstract
Background: Acute Invasive fungal rhinosinusitis (AIFR) is a life-threatening disease presents usually in immune-compromised patients with impaired neutrophilic response.
Aim: To study and statistically analyze the epidemiological factors leading to the observed increased incidence of invasive fungal rhinosinusitis in coronavirus disease-19 (COVID-19) diseased patients and identify the prognostic factors that may affect the course and outcome of the disease.
Methods: This case-control study was carried out on 23 patients diagnosed with acute invasive fungal sinusitis patients, patients with positive coronavirus or recently recovered from coronavirus infection admitted to tertiary or secondary centers in El-Gharbia governorate, and 46 participants as a control. The study was focused on the epidemiological predisposing factors that may affect the incidence of the disease.
Results: COVID-19 reporting and data system (CORAD), level of O2 saturation, PH, steroid therapy dose and duration, duration of O2 therapy, and anterior septal deviation were insignificantly different between the two studied groups. Random blood sugar (RBS), neutropenia, and type O2 therapy were significantly different between the two studied groups. Steroid therapy dose and duration were significantly higher in the patients’ group than control group (P
References
J M Gwaltney (1985) Virology and immunology of the common cold. 23(4), 265-71.
D B Jernigan, COVID C, Team R (2020) Update: public health response to the coronavirus disease 2019 outbreak—United States, February 24, 2020. 69(8), 216-25.
Control CfD, Prevention, Control CfD, Prevention (2020) Clinical questions about COVID-19: questions and answers. 210-22.
For Immunization NC (2021) Science Brief: SARS-CoV-2 and Surface (Fomite) Transmission for Indoor Community Environments. 12-4.
J W Tang, L C Marr, Y Li, S J Dancer (2021) Covid-19 has redefined airborne transmission. 120-36.
M Abdulnoor (2022) Public Health Applications of Genomic Epidemiology during the COVID-19 Pandemic.
S Hautea, P Parks, B Takahashi, J Zeng (2021) Showing they care (or don't): Affective publics and ambivalent climate activism on TikTok. 7(2), 20-56.
F Shahid, A Hussain, N Ul Ain, M Bhatti Mehmood (2023) Invasive Fungal Rhinosinusitis: Clinical and Surgical Factors Affecting Its Prognosis and Disease-Specific Morality. 15(5), e38830.
M Hoenigl, A F Talento (2021) Fungal Infections Complicating COVID-19.
C C Blyth, K Hale, P Palasanthiran, T O'Brien, M H Bennett (2010) Antifungal therapy in infants and children with proven, probable or suspected invasive fungal infections. (2), 35-45.
H G Schiefer (1997) Mycoses of the urogenital tract. 40(2), 33-6.
V Monceaux, C Chiche-Lapierre, C Chaput, V Witko-Sarsat, M-C Prevost, C T Taylor (2016) Anoxia and glucose supplementation preserve neutrophil viability and function. 128(7), 993-1002.
S J Blosser, R A Cramer (2012) SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A). 56(1), 248-57.
M J Carlile, S C Watkinson, G W Gooday (2001)
G Chamilos, M S Lionakis, D P Kontoyiannis (2018) Call for action: Invasive fungal infections associated with ibrutinib and other small molecule kinase inhibitors targeting immune signaling pathways. 66(1), 140-8.
C Ding, Y Zhang, Z Yang, J Wang, A Jin, W Wang (2017) Incidence, temporal trend and factors associated with ventilator-associated pneumonia in mainland China: a systematic review and meta-analysis. 17(5), 1-10.
M Wolf, S Naftali, R C Schroter, D Elad (2004) Air-conditioning characteristics of the human nose. 118(2), 87-92.
S Grutzenmacher, D M Robinson, K Grafe, C Lang, G Mlynski (2006) First findings concerning airflow in noses with septal deviation and compensatory turbinate hypertrophy – a model study. 68(20), 199-205.
B Spellberg, D P Kontoyiannis, D Fredricks, M I Morris, J R Perfect, P V Chin-Hong (2012) Risk factors for mortality in patients with mucormycosis. 50(6), 611-8.
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