Adoptive Transfer of Immune Response in a Xenogenic System
Abstract
Rupert Billingham, Leslie Brent and Peter Medawar showed in 1953 that the state of sensitization to an antigen could be passively transferred to a recipient with a transplant of specifically sensitized donor lymphoid cells, which continued to function successfully in their new body [1]. This transfer of immunity was designated by R. Billigham and co-authors [2] as adoptive transfer, and the immunity itself was called adoptive or perceived immunity.
Adoptive transfer of lymphocytes is currently used to assess the functional activity of individual cell forms or to develop cell therapy techniques, for example in experimental oncology, using T-lymphocytes specifically sensitized to tumor antigens [3, 4, 5, 6, 7]. However, the problem of adoptive transfer of immune response remains far from being resolved. It is believed that adoptive transfer of sensitization to a specific antigen is possible only through the introduction of lymphoid cells of an immunized donor to the recipient [8, 9, 10, 11].
We have previously shown that adoptive transfer in a syngeneic system (BALB/c mice) can also be accomplished via platelets [12 ]. In the available literature, we have not found information on the possibility of adoptive transfer of sensitization via platelets in a xenogenic system. In this regard, the goal of the present study was chosen.
References
André-René Blaudszun, Jun Kim, Wooram Um, Hong Yeol Yoon, Man Kyu Shim, Kwangmeyung Kim (2023) Adoptive Transfer of Photosensitizer-Loaded Cytotoxic T Cells for Combinational Photodynamic Therapy and Cancer Immuno-Therapy. 15(4), 1295. https://doi.org/10.3390/pharmaceutics15041295
Parsa R, Andresen P, Gillett A, Mia S (2012) Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice. 61(11), 2881-92. https://doi.org/10.2337/db11-1635
T-cell Transfer Therapy. https://www.cancer.gov/about-cancer/treatment/types/biomarker-testing-cancer-treatment
S.A. Pleskanovskaya (2020) Adaptive transfer of the immune response – new approaches. 2, 11-17.
T Bleul, X Zhuang, A Hildebrand, C Lange, D Böhringer, G Schlunck, T Reinhard, T Lapp (2021) Different Innate Immune Responses in BALB/c and C57BL/6 Strains following Corneal Transplantation. (1), 49-59. https://doi.org/10.1159/000509716
Н.В. Мясная, А.А. Чурин, О.С. Борсук (2002) Особенности реакций иммунной системы мышей разных линий. 133(10), 437-439.
A.G. Perez, J.F. Lana, A.A. Rodrigues, A.C. Luzo, W.D. Belangero, M.H. Santana (2014) Relevant aspects of centrifugation step in the preparation of platelet-rich plasma. 176060. https://doi.org/10.1155/2014/176060
С.А. Плескановская (1982) Клеточный и гуморальный иммунный ответ при кожном лейшманиозе (экспериментальные исследования и наблюдения на боль-ных). 25.
С.А. Плескановская (1997) Гранулоциты и гранулоцитарный индекс. 23-26.
С.А. Плескановская, А.Х. Тачмухаммедова (2015) Иммуногематологические критерии оценки иммунного ответа мышей на эритроциты барана. 55-58.
С.А. Плескановская, А.Х. Тачмухаммедова (2016) Способ контроля формирования иммунного ответа экспериментальных животных на тимусзависимый антиген - эритроциты барана.
Robert E. Marx (2001) Platelet-reach plasma (PRP): what is PRP and what is not PRP?. 10(4). http://www.dental-azbuka.ru/articles/2-2/1-article
A. S. Weyrich, S. Lindemann, N. D. Tolley, et al. (2004) Change in protein phenotype without a nucleus: translational control in platelets. 30(4), 491-498. https://doi.org/10.1055/s-2004-833484
J. B. Kral, W. C. Schromaier, M. Salzmann, A. Assinger (2016) Platelet Interaction with Innate Immune system. 43(2), 78-88. https://doi.org/10.1159/000444807
(2009) Тромбоцитный концентрат. (3), 20-22.
David Furman, Mark M. Davis (2015) New approaches to understanding the immune response to vaccination and infection. 33(40), 5271-81. https://doi.org/10.1016/j.vaccine.2015.06.117
Rolf M. Zinkernagel (2002) On differences between immunity and immunological memory. 14(4), 523-536. https://doi.org/10.1016/S0952-7915(02)00367-9
Rolf M. Zinkernagel (2012) Immunological memory ≠ protective immunity. 69(10), 1635-40. https://doi.org/10.1007/s00018-012-0972-y
Rolf M. Zinkernagel (2000) What is missing in immunology to understand immunity?. 1(3), 181-5. https://doi.org/10.1038/79712
Rolf M. Zinkernagel, Hans Hengartner (2006) Protective ‘immunity’ by pre-existent neutralizing antibody titers and preactivated T cells but not by so-called ‘immunological memory’. 211(1), 310-319. https://doi.org/10.1111/j.0105-2896.2006.00402.x
S. Rasković, A. Perić-Popadić, Z. Jovisić, M. Bogić (1998) The role of thrombocytes in allergic inflammation. 126(1-2), 54-60.
A. S. Weyrich, G. A. Zimmerman (2004) Platelets: signaling cells in the immune continuum. 25(9), 489-95. https://doi.org/10.1016/j.it.2004.07.003
Visai Muruganandah, Andreas Kupz (2022) Immune responses to bacterial lung infections and their implications for vaccination. 34(5), 231–248. https://doi.org/10.1093/intimm/dxab109
М. Пантелеев, Е. Артеменко, И. Демина (2018) Субпопуляции тромбоцитов крови и механизмы их взаимодействия с белками системы свертывания. https://doi.org/10.24022/1997-3187-2018-12-3-260-274
P M Galagali, A A Kinikar, V S Kumar (2022) Vaccine Hesitancy: Obstacles and Challenges. 241-248. https://doi.org/10.1007/s40124-022-00278-9
Appendices to the report of the sage working group. https://cdn.who.int/media/docs/default-source/immunization/sage/2014/october/2-sage-appendicies-background-final.pdf?sfvrsn=2259f1bf_4
(2020) Who Position Paper Process. https://www.who.int/vaccine_position_papers/position_paper_process.pdf
Г.Г. Онищенко, В.Ю. Смоленский, Е.Б. Ежлова, Ю.В. Демина, В.П. Топорков, А.В. Топорков, М.Н. Ляпин, В.В. Кутырев (2013) Концептуальные основы биологической безопасности. Часть I. 4. https://doi.org/10.15690/vramn.v68i10.781
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