The Comparative Analysis of Efficacy and Safety Parameters of Insulin Degludec Versus Insulin Glargine: A Systematic Review and Meta- Analysis (2023)

Abstract

Insulin glargine and degludec represent the second-generation basal insulins invented to fill in a clinical need for the insulin which matches the normal pattern of insulin secretion as closely as possible. Both insulins showed reduced rates of hypoglycaemia in real-world patients compared to the first-generation basal insulins. However, according to several studies, decludec demonstrated superiority in reaching optimal fasting plasma glucose targets without increasing risk of nocturnal hypoglycaemia. The aim of this study is to compare the efficacy and safety parameters of insulin degludec versus insulin degludec.